Nanomechanics of Ig-like domains of human contactin (BIG-2)

Nanomechanics of Ig-like domains of human contactin (BIG-2)

Contactins are modular extracellular cell matrix proteins that are present in the brain, and they are responsible for the proper development and functioning of neurons. They contain six immunoglobulin-like IgC2 domains and four fibronectin type III repeats. The interactions of contactin with other proteins are poorly understood. The mechanical properties of all IgC2 domains of human contactin 4...

Oligomeric Structure of the MALT1 Tandem Ig-Like Domains

BACKGROUND Mucosa-associated lymphoid tissue 1 (MALT1) plays an important role in the adaptive immune program. During TCR- or BCR-induced NF-κB activation, MALT1 serves to mediate the activation of the IKK (IκB kinase) complex, which subsequently regulates the activation of NF-κB. Aggregation of MALT1 is important for E3 ligase activation and NF-κB signaling. PRINCIPAL FINDINGS Unlike the iso...

Separate Functional Domains of Human MD - 2 Mediate Toll - Like

A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin.

The skin mucus IgM is an important molecule in the mucosal immune system of teleost skin. However, the transport mechanism associated with this molecule has yet to be clarified. In this study, we isolated a gene encoding a polymeric Ig receptor (pIgR) from a species of teleost fish, Takifugu rubripes (fugu). This gene is known to be an Ig transporter in the intestine of mammals. Our studies fur...

Semistar dimension of polynomial rings and Prufer-like domains

Let $D$ be an integral domain and $star$ a semistar operation stable and of finite type on it. We define the semistar dimension (inequality) formula and discover their relations with $star$-universally catenarian domains and $star$-stably strong S-domains. As an application, we give new characterizations of $star$-quasi-Pr"{u}fer domains and UM$t$ domains in terms of dimension inequal...